EFFECT OF NITRIC-OXIDE ON L-[H-3]GLUTAMATE BINDING TO RAT-BRAIN SYNAPTIC-MEMBRANES

被引：38

作者：

FUJIMORI, H ^{[1
]}

PANHOU, H ^{[1
]}

机构：

[1] SETSUNAN UNIV,FAC PHARMACEUT SCI,DEPT ANALYT CHEM HYG,45-1 NAGAOTOGE CHO,HIRAKATA,OSAKA 57301,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 554卷 / 1-2期

关键词：

NITRIC OXIDE; L-GLUTAMATE BINDING; NEUROTRANSMISSION; SYNAPTIC MEMBRANE RECEPTOR; SODIUM NITROPRUSSIDE; REGULATION OF NITRIC OXIDE;

D O I：

10.1016/0006-8993(91)90217-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO), which is spontaneously generated from sodium nitroprusside, was shown to inhibit L-[H-3]glutamate binding to rat brain synaptic membranes in a concentration-dependent manner. The L-glutamate binding inhibited by NO, was largely recoverable by the addition of hemoglobin, a scavenger of NO, to the assay medium. These results suggest that NO may play an important role in the modulation of excitatory neurotransmission through direct interaction of L-glutamate binding to its physiological synaptic membrane receptors.

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页码：355 / 357

页数：3

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