A new research method was developed to investigate the influence of an increase in seismicity from one zone on the increase in other zones nearby. By applying the developed method to each main seismic zone in Uzbekistan, we specify the external seismic zone activation, which has the greatest impact on activation within the research zone. We also identify each external seismic zone characterized by high seismic activity and large seismic potential that has the greatest impact on each seismic zone in Uzbekistan. (C) 2015, Institute of Seismology, China Earthquake Administration, etc. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.