Impaired plasticity of hippocampal synaptic transmission in rats exposed to prenatal hypoxia is normalized by treatment with nootropic dipeptides

Experiments on hippocampal slices from young rats exposed to hypobaric hypoxia during in utero development revealed enhanced responsiveness (an increase in a CA1 field response amplitude) and reduced plasticity (a low incidence of field response long-term potentation following high-frequency stimulation) of CA1 pyramidal neurons. Postnatal treatment of animals with piracetam peptide analogs constructed on the basis of pyroglutamate and proline normalized both these physiological indices.