HIGH CEREBROSPINAL-FLUID AND SERUM LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA IN ASYMPTOMATIC HIV-1 SEROPOSITIVE INDIVIDUALS - CORRELATION WITH INTERLEUKIN-2 AND SOLUBLE IL-2 RECEPTOR

被引：17

作者：

CIARDI, M

SHARIEF, MK

THOMPSON, EJ

SALOTTI, A

VULLO, V

SORICE, F

CIRELLI, A

机构：

[1] UCL NATL HOSP NEUROL & NEUROSURG, INST NEUROL, LONDON WC1N 3BG, ENGLAND

[2] UNIV ROMA LA SAPIENZA, INST INFECT DIS, ROME, ITALY

[3] UNIV PISA, DEPT INFECT DIS, PISA, ITALY

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 125卷 / 02期

关键词：

HIV-1; AIDS; CEREBROSPINAL FLUID; TUMOR NECROSIS FACTOR; INTERLEUKIN-2; SOLUBLE IL-2 RECEPTOR;

D O I：

10.1016/0022-510X(94)90031-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The relationship between tumour necrosis factor-alpha (TNF-alpha) and the interleukin-2 (ILL-2) system in HIV-1 infection is important in understanding the dynamics of early immune response before the development of acquired immunodeficiency syndrome. Levels of TNF-alpha, IL-2 and soluble IL-2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) samples from 31 asymptomatic HIV-1 seropositive individuals were measured. High levels of TNF-alpha were detected in CSF of 17 (55%) and serum of 22 (71%) subjects, 15 (88%) of whom had elevated CSF IL-2 levels and 16 (94%) had high sIL-2R levels. Moreover, CSF levels of TNF-alpha significantly correlated with CSF levels of IL-2 and sIL-2R. TNF-alpha, IL-2 and sIL-2R seem to be released within the intrathecal compartment early in the course of HIV-1 infection. In view of the known cytotoxic effects of TNF-alpha, an early release may contribute to subsequent development of neurological complications.

引用

页码：175 / 179

页数：5

共 29 条

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