PLASMA-CORTISOL AND 11-DEOXYCORTISOL ACTIVITY IN DEPRESSED-PATIENTS AND NORMAL VOLUNTEERS

被引:3
作者
SCHWEITZER, I [1 ]
TUCKWELL, VM [1 ]
MAGUIRE, KP [1 ]
TILLER, JWG [1 ]
HARRISON, LC [1 ]
DAVIES, BM [1 ]
机构
[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,BURNET CLIN RES UNIT,PARKVILLE,VIC 3050,AUSTRALIA
基金
英国医学研究理事会;
关键词
D O I
10.1016/0306-4530(91)90002-B
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Plasma cortisol and 11-deoxycortisol were measured in 30 depressed patients and 110 normal volunteers before and after a 1.0 mg dexamethasone suppression test (DST). Post-dexamethasone plasma cortisol, 11-deoxycortisol and the cortisol/11-deoxycortisol ratio were significantly higher in the depressives compared to the controls, even when age and sex were taken into account. Predexamethasone plasma cortisol, post-dexamethasone cortisol, 11-deoxycortisol and their ratio were significantly higher in the cortisol nonsuppressors than in the suppressors. The measurement of post-dexamethasone 11-deoxycortisol and the ratio did not differentiate between endogenous and reactive depression. Using the normative data, we explored several methods for determining a criterion value to define abnormal post-dexamethasone plasma 11-deoxycortisol and the cortisol/11-deoxycortisol ratio in depressed patients. All showed poor sensitivity and a low positive predictive value for depression. The measurement of 11-deoxycortisol thus does not enhance the clinical utility of the DST.
引用
收藏
页码:375 / 382
页数:8
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