INFLUENCE OF MOUSE GENOTYPE ON THE CHANGES IN BRAIN CYCLIC NUCLEOTIDE LEVELS INDUCED BY ACUTE ALCOHOL ADMINISTRATION

被引：12
作者：
CHURCH, AC [1 ]
FELLER, D [1 ]
机构：
[1] UNIV MISSOURI,DEPT BIOCHEM,COLUMBIA,MO 65212
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 03期
关键词：
Cyclic AMP; Cyclic nucleotides; Ethanol hypothermia; Ethanol narcosis; Psychopharmacogenetics;
D O I：
10.1016/0091-3057(79)90193-X
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Two mouse strains (C57BL/6By and BALB/cByJ) were found to differ widely in their sleep-time response to ethanol (3 g/kg), but showed no difference in their hypothermic response to the same ethanol dose. Comparison of brain cyclic nucleotide levels in the two strains revealed a strain difference in the brain cyclic AMP response to ethanol but no strain difference in the magnitude of the brain cyclic GMP change. Alcohol produced a significant drop in cerebellar cyclic GMP in both strains, and a decrease in cerebellar cyclic AMP in C57BL/6By mice. The cyclic AMP/cyclic GMP ratio increased following alcohol in the cerebellum of BALB/cByJ mice but not C57BL/6By mice. The results are discussed in terms of possible relationships between alcohol-induced changes in neurochemistry and behavior. © 1979.
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收藏
页码：335 / 338
页数：4
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