USE OF MANNOSYLATED LIPOSOMES FOR INVIVO TARGETING OF A MACROPHAGE ACTIVATOR AND CONTROL OF ARTIFICIAL PULMONARY METASTASES

被引：32

作者：

BARRATT, GM ^{[1
]}

NOLIBE, D ^{[1
]}

YAPO, A ^{[1
]}

PETIT, JF ^{[1
]}

TENU, JP ^{[1
]}

机构：

[1] CEA,INST PROTECT & SURETE NUCL,DEPT PROTECT SANIT,SPEGTCE,TOXICOL TRANSURANIENS LAB,F-91680 BRUYERES CHATEL,FRANCE

来源：

ANNALES DE L INSTITUT PASTEUR-IMMUNOLOGY | 1987年 / 138卷 / 03期

关键词：

Liposome; Mannose; Macrophage; MDP; Tumeur; Ciblage thérapeutique; Immunomodulation; Endotoxine; MTP-CHOL; Metastases; Rat; Métastases; Tumour; Drug delivery; Endotoxin;

D O I：

10.1016/S0769-2625(87)80054-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

From a mannosylated mycobacterial phospholipid, we prepared an original type of liposome which was taken up by macrophages by means of the mannose/fucose receptor. When a lipophilic immunomodulator, MDP-L-alanylcholesterol (MTP-CHOL) was included in such liposomes, they were able to activate WAG rat alveolar macrophages for cytotoxicity against syngeneic tumour cells in vitro. The presence of suboptimal levels of endotoxin was essential for this activation. Cytotoxic macrophages could also be induced in vivo by injecting immunomodulator-loaded liposomes intravenously 24 h before harvesting macrophages. A decrease in experimental pulmonary colonies arising from i.v. injected tumour cells was observed following repeated administration of such liposomes. © 1987, Elsevier. All rights reserved.

引用

页码：437 / 450

页数：14

共 38 条

[1] MURAMYL PEPTIDES - IMMUNOMODULATORS, SLEEP FACTORS, AND VITAMINS [J].