NOVEL-APPROACH FOR SYNTHESIS OF (+/-)-CALANOLIDE-A AND ITS ANTI-HIV ACTIVITY

被引：0

作者：

KUCHERENKO, A ^{[1
]}

FLAVIN, MT ^{[1
]}

BOULANGER, WA ^{[1
]}

KHILEVICH, A ^{[1
]}

SHONE, RL ^{[1
]}

RIZZO, JD ^{[1
]}

SHEINKMAN, AK ^{[1
]}

XU, ZQ ^{[1
]}

机构：

[1] MEDICHEM RES INC,LEMONT,IL 60439

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 31期

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D O I：

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中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Anti-HIV agent (+/-)-calanolide A (1) has been synthesized. The key intermediate, chromene 5, was synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan-2-ol. The anti-HN activity for synthetic (+/-)-1 has been determined and compared with the natural product.

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页码：5475 / 5478

页数：4

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