A POSSIBLE INVOLVEMENT OF VIP IN FEEDING-INDUCED SECRETION OF ACTH AND CORTICOSTERONE IN THE RAT

被引:18
作者
ALEXANDER, LD
EVANS, K
SANDER, LD
机构
[1] CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SCH MED,DIV HYPERTENS,CLEVELAND,OH 44106
[2] MEHARRY MED COLL,SCH GRAD STUDIES & RES,DEPT PHYSIOL,NASHVILLE,TN 37208
关键词
PITUITARY; ADRENAL; FOOD-INTAKE; HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; BRAIN GUT PEPTIDE; RAT; PARAVENTRICULAR NUCLEUS NEUROPEPTIDES; MICROINJECTION;
D O I
10.1016/0031-9384(95)00058-Q
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
For decades it has been known that brainl gut peptides are released during the ingestion of a meal. Although a multitude of actions have been attributed to these peptides acting in the brain, including the release or inhibition of a variety of pituitary hormones, the actual physiological roles of these substances in the brain have not been confirmed. For the first time, we have demonstrated that feeding-induced hypothalamic-pituitary-adrenal (HPA) secretion may involve the brainl gut peptide, vasoactive intestinal peptide (VIP), acting in the paraventricular nucleus (PVN) of the hypothalamus. The effects of 24 h fasting and refeeding on the release of plasma ACTH and CORT secretion in male rats were investigated. Blood samples were collected 5 min prior to PVN administration of saline or VIP antagonist, [Lsy(1),Pro(2,5),Arg(3,4),Tyr(6)]-VIP and 30 min after refeeding. Plasma ACTH and CORT concentrations were significantly increased by 43 and 485%, respectively, by 30 min ingestion of food. Pretreatment with the VIP antagonist (0.75 and 1.5 nmol/rat) significantly reduced the food-induced ACTH response by 69 and 76% and the CORT response by 58 and 65%, respectively. There were no significant differences in food-intake among groups. These results suggest that one potential role of hypothalamic VIP may involve activation of hypothalamic-releasing factors to regulate ACTH and CORT levels during or after a meal.
引用
收藏
页码:409 / 413
页数:5
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