SYNTHESIS AND ANXIOLYTIC ACTIVITY OF 6-(SUBSTITUTED-PHENYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINES

被引：92
作者：
ALBRIGHT, JD
MORAN, DB
WRIGHT, WB
COLLINS, JB
BEER, B
LIPPA, AS
GREENBLATT, EN
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 05期
关键词：
D O I：
10.1021/jm00137a020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：592 / 600
页数：9
相关论文
共 50 条
[1]   USE OF ALPHA-(ARYL)-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) IN 1,4-ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS AND NITRILES - VERSATILE SYNTHETIC ROUTE TO 6-ARYL-3(2H)PYRIDAZINONES [J].
ALBRIGHT, JD ;
MCEVOY, FJ ;
MORAN, DB .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (06) :881-892
[2]   ANXIOLYTIC VERSUS SEDATIVE PROPERTIES IN THE BENZODIAZEPINES SERIES - DIFFERENCES IN STRUCTURE-ACTIVITY-RELATIONSHIPS [J].
BABBINI, M ;
GAIARDI, M ;
BARTOLETTI, M .
LIFE SCIENCES, 1979, 25 (01) :15-22
[3]  
BACHMANN G, 1969, Patent No. 116829
[4]   INVITRO AND INVIVO INHIBITION BY ZOPICLONE OF BENZODIAZEPINE BINDING TO RODENT BRAIN RECEPTORS [J].
BLANCHARD, JC ;
BOIREAU, A ;
GARRET, C ;
JULOU, L .
LIFE SCIENCES, 1979, 24 (26) :2417-2420
[5]   PHARMACOLOGICAL CHARACTERIZATION OF BENZODIAZEPINE RECEPTORS IN BRAIN [J].
BRAESTRUP, C ;
SQUIRES, RF .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 48 (03) :263-270
[6]   URINARY AND BRAIN BETA-CARBOLINE-3-CARBOXYLATES AS POTENT INHIBITORS OF BRAIN BENZODIAZEPINE RECEPTORS [J].
BRAESTRUP, C ;
NIELSEN, M ;
OLSEN, CE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2288-2292
[7]   SPECIFIC BENZODIAZEPINE RECEPTORS IN RAT-BRAIN CHARACTERIZED BY HIGH-AFFINITY [DIAZEPAM-H-3] BINDING - (AFFINITY BINDING DIAZEPAM ANXIOLYTIC ACTIVITY BRAIN MEMBRANES REGIONAL DISTRIBUTION) [J].
BRAESTRUP, C ;
SQUIRES, RF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3805-3809
[8]   SEQUENTIAL METHOD FOR COMBINED SCREENING ANTIHYPERTENSIVE AND DIURETIC AGENTS IN THE SAME SPONTANEOUSLY HYPERTENSIVE RAT (SHR) [J].
CHAN, PS ;
POORVIN, D .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 1979, 1 (06) :817-830
[9]   6-PHENYL-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - SERIES OF HYPOTENSIVE AGENTS [J].
CURRAN, WV ;
ROSS, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) :273-281
[10]   DISPLACEMENT OF [H-3] DIAZEPAM BINDING IN RAT-BRAIN BY DIPYRIDAMOLE AND BY 1-METHYLISOGUANOSINE, A MARINE NATURAL PRODUCT WITH MUSCLE-RELAXANT ACTIVITY [J].
DAVIES, LP ;
COOK, AF ;
POONIAN, M ;
TAYLOR, KM .
LIFE SCIENCES, 1980, 26 (13) :1089-1095
12345