12-O-TETRADECANOYLPHORBOL-13-ACETATE STIMULATES THE TRANSCRIPTION OF THE HISTIDINE-DECARBOXYLASE GENE

被引：7
|
作者：
YATSUNAMI, K
NAKAGAWA, S
OHGO, M
YAMAMOTO, J
ICHIKAWA, A
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHYSIOL CHEM,SAKYO KU,KYOTO 606,JAPAN
[2] JAPAN TOBACCO INC,PHARMACEUT BASIC RES LABS,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN
来源：
AGENTS AND ACTIONS | 1993年 / 38卷
关键词：
D O I：
10.1007/BF01996445
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent tumor-promoting phorbol ester, stimulates histidine decarboxylase (HDC) activity in mouse mastocytoma P-815 cells. Activation of a transcriptional factor is believed to be involved in the effect of TPA. In vitro experiments indicated that TPA-induced HDC activation is caused by transcriptional activation of the HDC gene through the TPA-responsive element, TRE.
引用
收藏
页码：C155 / C157
页数：3
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