ENHANCED URINARY-EXCRETION OF LEUKOTRIENE E4 IN PATIENTS WITH MEVALONATE KINASE-DEFICIENCY

被引：15
|
作者：
MAYATEPEK, E
HOFFMANN, GF
BREMER, HJ
机构：
[1] University Children's Hospital, Heidelberg
来源：
JOURNAL OF PEDIATRICS | 1993年 / 123卷 / 01期
关键词：
D O I：
10.1016/S0022-3476(05)81548-3
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 ( n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.
引用
收藏
页码：96 / 98
页数：3
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