BIOSYNTHETIC PRECURSORS OF DEAZAFLAVINS

被引：26

作者：

REUKE, B ^{[1
]}

KORN, S ^{[1
]}

EISENREICH, W ^{[1
]}

BACHER, A ^{[1
]}

机构：

[1] TECH UNIV MUNICH,LEHRSTUHL ORGAN CHEM & BIOCHEM,LICHTENBERGSTR 4,W-8046 GARCHING,GERMANY

来源：

JOURNAL OF BACTERIOLOGY | 1992年 / 174卷 / 12期

关键词：

D O I：

10.1128/jb.174.12.4042-4049.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The incorporation of C-13 and C-14-labeled precursors into 5-deaza-7,8-didemethyl-8-hydroxyriboflavin (factor F0) was studied with growing cells of Methanobacterium thermoautotrophicum. 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione was incorporated into the deazaflavin and into riboflavin without dilution. Tyrosine and 4-hydroxyphenylpyruvate were incorporated into the deazaflavin and into cellular protein. 4-Hydroxybenzaldehyde was not incorporated. A reaction mechanism is proposed for the formation of the deazaflavin chromophore from 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione and tyrosine or 4-hydroxyphenylpyruvate.

引用

页码：4042 / 4049

页数：8

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