MEDULLARY BUT NOT CORTICAL THYMIC EPITHELIAL-CELLS PRESENT SOLUBLE-ANTIGENS TO HELPER T-CELLS

被引:90
作者
MIZUOCHI, T
KASAI, M
KOKUHO, T
KAKIUCHI, T
HIROKAWA, K
机构
[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PATHOL,ITABASHI KU,TOKYO 173,JAPAN
[2] UNIV TOKYO,INST MED SCI,DEPT ALLERGOL,TOKYO 108,JAPAN
关键词
D O I
10.1084/jem.175.6.1601
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Thymic epithelial cell lines (TECs) were established from newborn C57BL/6 mice. They were classified into two types (medullary and cortical TECs) by using the monoclonal antibody (Th-3) that recognizes the meshwork structure of thymic cortical epithelial cells. Antigen-presenting activity of each TEC was determined by using ovalbumin-specific, I-A(b)-restricted helper T cell lines. It was demonstrated that the medullary but not the cortical TECs functioned as antigen-presenting cells. This is the first evidence for the functional difference between the cortical and the medullary TEC.
引用
收藏
页码:1601 / 1605
页数:5
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