Synthesis and evaluation of a series of pyrimidine substituted 1,3,4-oxadiazole derivatives as antimicrobial and anti-inflammatory agents

被引：0

作者：

Palusa, Sanath Kumar Goud ^{[1
,2
]}

Udupi, Rajgopal H. ^{[2
]}

Himabindu, V ^{[1
]}

Sridhara, Ajjanna M. ^{[3
]}

机构：

[1] Jawaharlal Nehru Technol Univ Kukatpally, Dept Chem, Hyderabad 500072, Andhra Prades, India

[2] NET Pharm Coll, Dept Pharmaceut Chem, Raichur 584103, India

[3] Kuvempu Univ, Dept Ind Chem, Shimoga 577451, India

来源：

ORGANIC COMMUNICATIONS | 2011年 / 4卷 / 04期

关键词：

1,3,4-oxadiazole; pyrimidine; antibacterial; antifungal; anti-inflammatory;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel pyrimidine substituted 1,3,4-oxadiazole derivatives (11a-k) were synthesized from the condensation of different substituted aromatic carboxylic acids with substituted pyrimidine carboxy hydrazide using POCl3 as condensing agent. Their structures were characterized by physical and spectral studies. The synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.

引用

页码：82 / 93

页数：12

共 50 条

[1] Synthesis of some 1,3,4-oxadiazole derivatives as potential anti-inflammatory agents
Amir, Mohd
Javed, S. A.
Kumar, Harish
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2007, 46 (06): : 1014 - 1019
[2] Novel quinolone substituted 1,3,4-oxadiazole derivatives: design, synthesis, antimicrobial and anti-inflammatory potential
Sharma, Vishal
Das, Rina
Mehta, Dinesh Kumar
Sharma, Diksha
MOLECULAR DIVERSITY, 2024,
[3] Substituted-1,3,4-oxadiazole Indole Derivatives: Design, Synthesis, Characterization, and Evaluation of the Antimicrobial and Anti-Inflammatory Activities
Venkatesh, Medarametla
Yadav, Chappidi Hazarathaiah
Varalakshmi, Mavallur
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (11) : 2276 - 2289
[4] SYNTHESIS AND ANTIMICROBIAL EVALUATION OF A NEW SERIES OF COUMARIN SUBSTITUTED MERCAPTO 1,3,4-OXADIAZOLE DERIVATIVES
Purohit, Shriram S.
Kamlesh, Dhudat
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 23 (03) : 221 - 224
[5] SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES
Dhanya, K.
Revanasiddappa, B. C.
HETEROCYCLIC LETTERS, 2021, 11 (03): : 371 - 377
[6] Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents
Jayashankar, B.
Rai, K. M. Lokanath
Baskaran, N.
Sathish, H. S.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) : 3898 - 3902
[7] Synthesis and antibacterial activity of 1,3,4-oxadiazole substituted pyrimidine derivatives
Andrews, B.
Komathi, K.
Mohan, S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (04): : 591 - 597
[8] Synthesis, Characterization and Anti-Inflammatory Activity of Some 1,3,4-Oxadiazole Derivatives
Singh, Arvind Kumar
Lohani, M.
Parthsarthy, R.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2013, 12 (02): : 319 - 323
[9] Synthesis of substituted 1,3,4-oxadiazole derivatives
V. Mickevičius
R. Vaickelionienė
B. Sapijanskaitė
Chemistry of Heterocyclic Compounds, 2009, 45 : 215 - 218
[10] SYNTHESIS OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES
Mickevicius, V.
Vaickelioniene, R.
Sapijanskaite, B.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (02) : 215 - 218

← 1 2 3 4 5 →