Hindlimb Unloading Effects on beta-Endorphin Receptor in Rats

被引：0

作者：

Dizgah, Iraj Mirzaii ^{[1
]}

Chimeh, Pedram Bagheri ^{[1
]}

Far, Bahareh Tavakoli ^{[2
]}

机构：

[1] AJA Univ Med Sci, Sch Med, Dept Physiol, Tehran, Iran

[2] Alborz Univ Med Sci, Dept Physiol & Pharmacol, Karaj, Iran

来源：

ARCHIVES OF NEUROSCIENCE | 2018年 / 5卷 / 03期

关键词：

Hindlimb Unloading; Hippocampus; Prefrontal Cortex; Beta-Endorphin; Receptor;

D O I：

10.5812/archneurosci.62975

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Space is a harsh environment that affects the body in many ways. Humans venturing into the environment of space can have negative effects on the body. Objectives: This study focused on the effects of simulated microgravity on beta-endorphin receptor concentration. Methods: Rats (n =16) were divided in two groups (n = 8/group), freely moving (control group) and hindlimb unloading. A rat-tail suspension model was used in experiment groups for 14 days to explore the effect of simulated microgravity on the beta-endorphin receptor concentration in the hippocampus, brain stem, and prefrontal cortex. Results: The results showed that the concentration of beta-endorphin receptor in the brain stem and prefrontal cortex, but not in hippocampus, was significantly higher in hindlimb unloading rats than controls. Conclusions: It is possible that simulated microgravity may increase the beta-endorphin receptor expression in the prefrontal cortex and brain stem in the rat.

引用

页数：4

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