Insulin Resistance, Reason or Consequence Nonalcoholic Steatohepatitis (NASH)

Now a day's nonalcoholic fatty liver (NAFLD) is one of the most prevalent disease in children and adult people in all around the world. In some developed countries, it is the root cause of cryptogenic cirrhosis. NAFLD is a spectrum of lever disease that include simple steatosis or pathologic status such as steatohepatitis, fibrosis of cirrhosis. Nonalcoholic hepatitis (NASH) is a progressive type of liver disease witch refers to NAFLD and characterized with steatosis in hepatocytes, inflammation, necrosis and fibrosis and finally liver failure. The pathogenesis of NAFLD and NASH is closely associated with insulin resistance status. Insulin resistance may occur in peripheral or in liver. The resistance against insulin in hepatocytes is due to impaired function of insulin receptor substrate phosphorylation. Dysfunction of insulin receptor leads to failure to gluconeogenesis suppression. This impaired function of insulin receptors is seen in metabolic syndrome, diabetes type 2, obesity and some other condition. Regarding to high prevalence of NASH and it complications, in this review article, some aspect of NASH is studied.