Physiological Signaling and Structure of the HGF Receptor MET

被引：38

作者：

Baldanzi, Gianluca ^{[1
]}

Graziani, Andrea ^{[1
,2
]}

机构：

[1] Univ Piemonte Orientale, Dept Translat Med, Via Solaroli 17, I-28100 Novara, Italy

[2] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

来源：

BIOMEDICINES | 2015年 / 3卷 / 01期

关键词：

signaling pathways; tyrosine kinase receptor; protein-protein interaction; SH2; domain; post translational modification; signal transduction;

D O I：

10.3390/biomedicines3010001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The "hepatocyte growth factor" also known as "scatter factor", is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis.

引用

页码：1 / 31

页数：31

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