2 NEW CYTOTOXIC CYTOCHALASINS FROM XYLARIA-OBOVATA

被引：44

作者：

DAGNE, E

GUNATILAKA, AAL

ASMELLASH, S

ABATE, D

KINGSTON, DGI

HOFMANN, GA

JOHNSON, RK

机构：

[1] UNIV ADDIS ABABA, FAC SCI, ADDIS ABABA, ETHIOPIA

[2] SMITHKLINE BEECHAM PHARMACEUT, RES & DEV, KING OF PRUSSIA, PA 19406 USA

来源：

TETRAHEDRON | 1994年 / 50卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(01)85632-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylaria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.

引用

页码：5615 / 5620

页数：6

共 12 条

[1] ALLEY MC, 1988, CANCER RES, V48, P589
[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[3] BUCHI G, 1973, J AM CHEM SOC, V95, P5423, DOI 10.1021/ja00797a060
[4] COLE RJ, 1981, HDB TOXIC FUNGAL MET
[5] THE HIV-1 PROTEASE AS A THERAPEUTIC TARGET FOR AIDS
DEBOUCK, C
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (02) : 153 - 164
[6] EDWARDS R L, 1989, Journal of the Chemical Society Perkin Transactions I, P57
[7] METABOLITES OF THE HIGHER FUNGI .26. CUBENSIC ACID, 3,7,11,15-TETRAHYDROXY-18-(HYDROXYMETHYL)-2,4,6,10,14,16,20-HEPTAMETHYLDOCOSA-4E,8E,12E,16E-TETRAENOIC ACID, A NOVEL POLYSUBSTITUTED C22 FATTY-ACID FROM THE FUNGUS XYLARIA-CUBENSIS (MONT) FR WITH SUBSTITUENTS AND SUBSTITUTION PATTERN SIMILAR TO THE MACROLIDE ANTIBIOTICS
EDWARDS, RL
MAITLAND, DJ
WHALLEY, AJS
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (06): : 1411 - &
[8] STRUCTURES OF CYTOCHALASIN K, L AND M, ISOLATED FROM CHALARA-MICROSPORA
FEX, T
[J]. TETRAHEDRON LETTERS, 1981, 22 (28) : 2703 - 2706
[9] BIOACTIVE ERGOST-5-ENE-3-BETA,7-ALPHA-DIOL DERIVATIVES FROM PSEUDOBERSAMA-MOSSAMBICENSIS
GUNATILAKA, AAL
SAMARANAYAKE, G
KINGSTON, DGI
HOFFMANN, G
JOHNSON, RK
[J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11): : 1648 - 1654
[10] BRINE SHRIMP - A CONVENIENT GENERAL BIOASSAY FOR ACTIVE-PLANT CONSTITUENTS
MEYER, BN
FERRIGNI, NR
PUTNAM, JE
JACOBSEN, LB
NICHOLS, DE
MCLAUGHLIN, JL
[J]. PLANTA MEDICA, 1982, 45 (01) : 31 - 34

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