FUSION OF THE EWS GENE TO A DNA SEGMENT FROM 9Q22-31 IN A HUMAN MYXOID CHONDROSARCOMA

被引：32
作者：
GILL, S
MCMANUS, AP
CREW, AJ
BENJAMIN, H
SHEER, D
GUSTERSON, BA
PINKERTON, CR
PATEL, K
COOPER, CS
SHIPLEY, JM
机构：
[1] INST CANC RES,HADDOW LABS,MOLEC CARCINOGENESIS SECT,SUTTON SM2 5NG,SURREY,ENGLAND
[2] INST CANC RES,HADDOW LABS,PAEDIAT SECT,SUTTON,SURREY,ENGLAND
[3] INST CANC RES,HADDOW LABS,CELL BIOL & EXPTL PATHOL SECT,SUTTON,SURREY,ENGLAND
[4] NATL INST MED RES,LONDON NW7 1AA,ENGLAND
[5] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND
来源：
GENES CHROMOSOMES & CANCER | 1995年 / 12卷 / 04期
关键词：
D O I：
10.1002/gcc.2870120412
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Southern blot analyses revealed a rearrangement of the EWS gene in a skeletal human myxoid chondrosarcoma. Interphase fluorescence in situ hybridization (FISH) studies, using cosmid clones F7 and G9 that flank the EWS locus on 22q 12, confirmed the presence of this EW5 gene abnormality. Cloning the rearranged EWS DNA fragment and mapping by FISH demonstrated that the EWS gene is joined to DNA sequences localised in 9q22-31. These findings are consistent with previous cytogenetic reports of a recurrent t(9;22)(q22-31;q11-12) in the myxoid variant of chondrosarcoma and reveal involvement of the EWS gene in a fourth type of human sarcoma. (C) 1995 Wiley-Liss, inc.
引用
收藏
页码：307 / 310
页数：4
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