THE INFLUENCE OF SEVERITY OF SPINAL-CORD ISCHEMIA IN THE ETIOLOGY OF DELAYED-ONSET PARAPLEGIA

被引：107
作者：
MOORE, WM [1 ]
HOLLIER, LH [1 ]
机构：
[1] ALTON OCHSNER MED FDN & OCHSNER CLIN,DEPT SURG,1514 JEFFERSON HIGHWAY,NEW ORLEANS,LA 70121
来源：
ANNALS OF SURGERY | 1991年 / 213卷 / 05期
关键词：
D O I：
10.1097/00000658-199105000-00007
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
To clarify the cause of delayed-onset paraplegia, the authors evaluated the neurologic outcome after temporary (10 to 30 minutes) spinal cord ischemia in the awake rabbit. Loss of motor function occurred in less than 2 minutes in all animals. Restoration of flow within 16 minutes always resulted in full return of function, whereas with occlusion times of greater than 27 minutes all animals remained paralyzed. After temporary occlusion of 20 to 21 minutes, however, 71% of animals returned to normal neurologic function but developed delayed-onset paraplegia 14 to 48 hours later. This appears to be a reliable method for the creation of a model of delayed-onset paraplegia in the awake animal, and will facilitate more detailed studies of the pathophysiology of ischemia-induced paraplegia.
引用
收藏
页码：427 / 432
页数：6
相关论文
共 14 条
  • [1] EFFECTS OF THORACIC AORTIC OCCLUSION AND CEREBROSPINAL-FLUID DRAINAGE ON REGIONAL SPINAL-CORD BLOOD-FLOW IN DOGS - CORRELATION WITH NEUROLOGIC OUTCOME
    BOWER, TC
    MURRAY, MJ
    GLOVICZKI, P
    YAKSH, TL
    HOLLIER, LH
    PAIROLERO, PC
    [J]. JOURNAL OF VASCULAR SURGERY, 1989, 9 (01) : 135 - 144
  • [2] THROMBOXANE, PROSTACYCLIN, AND LEUKOTRIENES IN CEREBRAL-ISCHEMIA
    CHEN, ST
    HSU, CY
    HOGAN, EL
    HALUSHKA, PV
    LINET, OI
    YATSU, FM
    [J]. NEUROLOGY, 1986, 36 (04) : 466 - 470
  • [3] NEUROLOGICAL OUTCOME CORRELATED WITH SPINAL EVOKED-POTENTIALS IN A SPINAL-CORD ISCHEMIA MODEL
    CHENG, MK
    ROBERTSON, C
    GROSSMAN, RG
    FOLTZ, R
    WILLIAMS, V
    [J]. JOURNAL OF NEUROSURGERY, 1984, 60 (04) : 786 - 795
  • [4] A PROSPECTIVE RANDOMIZED STUDY OF CEREBROSPINAL-FLUID DRAINAGE TO PREVENT PARAPLEGIA AFTER HIGH-RISK SURGERY ON THE THORACOABDOMINAL AORTA
    CRAWFORD, ES
    SVENSSON, LG
    HESS, KR
    SHENAQ, SS
    COSELLI, JS
    SAFI, HJ
    MOHINDRA, PK
    RIVERA, V
    [J]. JOURNAL OF VASCULAR SURGERY, 1991, 13 (01) : 36 - 46
  • [5] THORACOABDOMINAL AORTIC-ANEURYSMS - PREOPERATIVE AND INTRAOPERATIVE FACTORS DETERMINING IMMEDIATE AND LONG-TERM RESULTS OF OPERATIONS IN 605 PATIENTS
    CRAWFORD, ES
    CRAWFORD, JL
    SAFI, HJ
    COSELLI, JS
    HESS, KR
    BROOKS, B
    NORTON, HJ
    GLAESER, DH
    [J]. JOURNAL OF VASCULAR SURGERY, 1986, 3 (03) : 389 - 404
  • [6] AMEBOID MICROGLIA AS EFFECTORS OF INFLAMMATION IN THE CENTRAL-NERVOUS-SYSTEM
    GIULIAN, D
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1987, 18 (01) : 155 - &
  • [7] HOLLIER LH, 1990, VASCULAR SURGERY COM, P295
  • [8] HOLLIER LH, 1987, J VASC SURG, V5, P524
  • [9] DETERIORATING STROKE MODEL - HISTOPATHOLOGY, EDEMA, AND EICOSANOID CHANGES FOLLOWING SPINAL-CORD ISCHEMIA IN RABBITS
    JACOBS, TP
    SHOHAMI, E
    BAZE, W
    BURGARD, E
    GUNDERSON, C
    HALLENBECK, JM
    FEUERSTEIN, G
    [J]. STROKE, 1987, 18 (04) : 741 - 750
  • [10] NORRIS DA, 1977, J LAB CLIN MED, V90, P569
12