RADICAL MEDIATED INTRAMOLECULAR [3-ATOM + 2-ATOM] ADDITION AND THE SYNTHESIS OF (+/-)-ROCAGLAMIDE - MODEL STUDIES

被引：37

作者：

FELDMAN, KS

BURNS, CJ

机构：

[1] Department of Chemistry, The Pennsylvania State University, University Park

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 15期

关键词：

D O I：

10.1021/jo00015a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclopenta[b]benzofuran ring system of the antileukemic natural product rocaglamide can be efficiently prepared by intramolecular [3 + 2] radical mediated addition. The stereochemical relationship that emerges between C(2) and C(3a) upon cyclization is identical with that seen in the natural product.

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页码：4601 / 4602

页数：2

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