STIMULATION OF MONOACYLGLYCEROL AND DIACYLGLYCEROL LIPASE ACTIVITIES BY BRADYKININ IN NEURAL CULTURES

被引：22

作者：

FAROOQUI, AA ^{[1
]}

ANDERSON, DK ^{[1
]}

FLYNN, C ^{[1
]}

BRADEL, E ^{[1
]}

MEANS, ED ^{[1
]}

HORROCKS, LA ^{[1
]}

机构：

[1] VET ADM MED CTR, CINCINNATI, OH 45220 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90910-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neural cultures of fetal mouse spinal cord, mouse neuroblastoma (NIE-115) and mixed primary glial cell cultures from neonatal rat brain display measurable activities of mono- and diacylglycerol lipases. Treatment of fetal mouse spinal cord cultures with bradykinin (10 nM) for 1-4 min resulted in a marked increase in specific activities of mono- and diacylglycerol lipases. This is the first direct demonstration that bradykinin can act through the lipase pathway. The increase in activities of lipases was dose and time dependent. The bradykinin response was blocked by [Thi5,8, D-Phe7]bradykinin, a bradykinin B-2 receptor antagonist, indicating that the bradykinin induced stimulation of lipase activities involves bradykinin receptors. © 1990.

引用

页码：1001 / 1009

页数：9

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