ALTERATION OF ACETYLCHOLINE METABOLISM IN THE BRAIN OF ZUCKER FATTY RAT

被引：8
|
作者：
OHKUMA, S
MA, F
KISHI, M
KURIYAMA, K
机构：
[1] Department of Pharmacology, Kyoto Prefectural University of Medicine, Kamikyo-Ku, Kyoto, 602, Kawaramachi-Hirokoji
来源：
NEUROCHEMISTRY INTERNATIONAL | 1990年 / 16卷 / 01期
关键词：
D O I：
10.1016/0197-0186(90)90129-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cerebral metabolism of acetylcholine (ACh) and [3H]quinuclidinyl benzilate([3H]QNB) binding to particulate fraction from the brain were examined using Zucker fatty rat. In all regions of the brain of fatty rat, ACh content showed a lower level than that of lean rat. Choline acetyltransferase activities in the striatum and medulla oblongata of fatty rat were significantly higher than those in lean rat, whereas the activities of acetylcholinesterase in the same brain regions of fatty rat were found to be significantly lower than those in lean rat. The [3H]QNB binding to particulate fraction obtained from the striatum of fatty rat was also found to be lower than that in lean rat. These results strongly suggest that the brain of Zucker fatty rat has impairments in the functions of cerebral cholinergic system. © 1990.
引用
收藏
页码：99 / 103
页数：5
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