ESTABLISHMENT OF A HUMAN CUTANEOUS T-CELL LYMPHOMA IN C.B-17 SCID MICE

被引：51

作者：

CHARLEY, MR ^{[1
]}

THARP, M ^{[1
]}

LOCKER, J ^{[1
]}

DENG, JS ^{[1
]}

GOSLEN, JB ^{[1
]}

MAURO, T ^{[1
]}

MCCOY, P ^{[1
]}

ABELL, E ^{[1
]}

JEGASOTHY, B ^{[1
]}

机构：

[1] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15213

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1990年 / 94卷 / 03期

关键词：

D O I：

10.1111/1523-1747.ep12874500

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Investigation into the immunobiology of cutaneous T-cell lymphomas (CTCL) would be facilitated by the development of a suitable experimental system. The recent use of mice with severe combined immune deficiency (SCID) as a vehicle to study the human immune system prompted us to try to establish CTCL in SCID mice. We found that a CD4+ lymphocytic infiltrate characteristic of CTCL was maintained within patient skin grafts in place on natural killer cell depleted SCID mice for the month of observation. CTCL cells were not found outside the human skin graft. This chimeric model using SCID mice and patient lesional skin should provide a useful tool to characterize CTCL/skin microenvironmental interactions and to test new therapeutic approaches. © 1990.

引用

页码：381 / 384

页数：4

共 14 条

[1] APPEARANCE OF A CELL-SURFACE ANTIGEN ASSOCIATED WITH THE ACTIVATION OF PERITONEAL-MACROPHAGES IN MICE [J].

AKAGAWA, KS ;

TOKUNAGA, T .

MICROBIOLOGY AND IMMUNOLOGY, 1982, 26 (09) :831-842

[2]

BILLINGHAM RE, 1961, TRANSPLANTATION TISS, P1

[3] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE [J].

BOSMA, GC ;

CUSTER, RP ;

BOSMA, MJ .

NATURE, 1983, 301 (5900) :527-530

[4]

CHARLEY M, 1989, J INVEST DERMATOL, V92, P411

[5] STUDIES ADDRESSING THE MECHANISM OF ANTI-ASIALO GM1 PREVENTION OF GRAFT-VERSUS-HOST DISEASE DUE TO MINOR HISTOCOMPATIBILITY ANTIGENIC DIFFERENCES [J].

CHARLEY, MR ;

MIKHAEL, A ;

HOOT, G ;

HACKETT, J ;

BENNETT, M .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1985, 85 (01) :S121-S123

[6] BASE SEQUENCE STUDIES OF 300 NUCLEOTIDE RENATURED REPEATED HUMAN DNA CLONES [J].

DEININGER, PL ;

JOLLY, DJ ;

RUBIN, CM ;

FRIEDMANN, T ;

SCHMID, CW .

JOURNAL OF MOLECULAR BIOLOGY, 1981, 151 (01) :17-33

[7]

DORSHKIND K, 1985, J IMMUNOL, V134, P3798

[8] THE HUMAN INTERLEUKIN-2 RECEPTOR - NORMAL AND ABNORMAL EXPRESSION IN T-CELLS AND IN LEUKEMIAS INDUCED BY THE HUMAN T-LYMPHOTROPIC RETROVIRUSES [J].

GREENE, WC ;

LEONARD, WJ ;

DEPPER, JM ;

NELSON, DL ;

WALDMANN, TA .

ANNALS OF INTERNAL MEDICINE, 1986, 105 (04) :560-572

[9] THE SCID-HU MOUSE - MURINE MODEL FOR THE ANALYSIS OF HUMAN HEMATOLYMPHOID DIFFERENTIATION AND FUNCTION [J].

MCCUNE, JM ;

NAMIKAWA, R ;

KANESHIMA, H ;

SHULTZ, LD ;

LIEBERMAN, M ;

WEISSMAN, IL .

SCIENCE, 1988, 241 (4873) :1632-1639

[10] TRANSFER OF A FUNCTIONAL HUMAN IMMUNE-SYSTEM TO MICE WITH SEVERE COMBINED IMMUNODEFICIENCY [J].

MOSIER, DE ;

GULIZIA, RJ ;

BAIRD, SM ;

WILSON, DB .

NATURE, 1988, 335 (6187) :256-259

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