BINDING TO MOUSE SKIN DNA OF BENZO[A]PYRENE, ITS 7,8-DIOL AND 7,8-DIOL-9,10-EPOXIDES IN RELATION TO THE TUMORIGENICITY OF THESE COMPOUNDS

被引：29

作者：

BROOKES, P

机构：

[1] Chemical Carcinogenesis Division, Institute of Cancer Research, Pollards Wood Research Station, Chalfont St. Giles, Buckinghamshire HP8 4SP, Nightingales Lane

来源：

CANCER LETTERS | 1979年 / 6卷 / 4-5期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0304-3835(79)80047-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tritium labelled and carbon-14 labelled benzo[a]pyrene (BP), (±)trans 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol), (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene and (±)-7α, 8β-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]-pyrene were applied to the shaved backs of mice. After 24 h the DNA was isolated from the treated skin and the extent of hydrocarbon binding was determined. The level of DNA binding is considered in relation to the previously reported carcinogenicity of the various benzo[a]pyrene derivatives. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：285 / 289

页数：5

共 19 条

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