SECONDARY METABOLITES OF THE ASPEN FUNGUS STACHYBOTRYS-CYLINDROSPORA

The secondary metabolites produced by the fungus Stachybotrys cylindrospora, which is known to be strongly antagonistic to the blue-stain fungus Ceratocystiopsis crassivaginata, have been examined. The compounds responsible for the antifungal activity are trichodermin (5) and trichodermol (6), two previously known mycotoxins belonging to the trichothecene family. The other metabolites, stachybotrydial (1), stachybotramide (8), and 6,8-dihydroxy-3,5,7-trimethylisochroman (7), although not active against C. crassivaginata, are new natural products. The structures of the new compounds were established by spectroscopic techniques.