2ND TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN AND UNCONJUGATED ESTRIOL LEVELS FOR SOME CONGENITAL-MALFORMATIONS

Maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotropin (hCG) and unconjugated oestriol (uE3) concentrations were measured in maternal serum samples from 21 pregnancies with neural-tube defects, 4 pregnancies with ventral wall defects (VWD) and 1662 unaffected pregnancies in women. These congenital malformations were confirmed by ultrasound scanning. The mean multiplate of the median (MoM) for AFP and uE3 was significantly different from the control values in cases of open NTD (AFP median MoM = 5,95, p < 0,001, uE3 median MoM = 0,2, p < 0,001), while hCG values did not differ from those of matched controls (hCG median MoM = 0,9). The biological basis of altered levels of uE3 in pregnancies with fetal NTDs is unclear.