ULTRASTRUCTURAL ALTERATIONS INDUCED BY 1-METHYL-4-PHENYLPYRIDINIUM (MPP+) IN CANINE SUBSTANTIA NIGRA AND RAT MESENCEPHALON INVITRO

被引：12

作者：

CHRISTIEPOPE, BC ^{[1
]}

BURNS, RS ^{[1
]}

WHETSELL, WO ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,DEPT PSYCHIAT,NASHVILLE,TN 37232

来源：

EXPERIMENTAL NEUROLOGY | 1989年 / 104卷 / 03期

关键词：

D O I：

10.1016/0014-4886(89)90035-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：235 / 240

页数：6

共 24 条

[1] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[2] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[3]

CHIBA K, 1985, BIOCHEM BIOPH RES CO, V128, P1229

[4]

CHIEUH CC, 1984, EUR J PHARMACOL, V100, P189

[5] PARGYLINE AND DEPRENYL PREVENT THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MONKEYS [J].

COHEN, G ;

PASIK, P ;

COHEN, B ;

LEIST, A ;

MYTILINEOU, C ;

YAHR, MD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (01) :209-210

[6] EVIDENCE FOR NEUROMELANIN INVOLVEMENT IN MPTP-INDUCED NEUROTOXICITY [J].

DAMATO, RJ ;

ALEXANDER, GM ;

SCHWARTZMAN, RJ ;

KITT, CA ;

PRICE, DL ;

SNYDER, SH .

NATURE, 1987, 327 (6120) :324-326

[7] SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN [J].

DAMATO, RJ ;

LIPMAN, ZP ;

SNYDER, SH .

SCIENCE, 1986, 231 (4741) :987-989

[8] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].

DAVIS, GC ;

WILLIAMS, AC ;

MARKEY, SP ;

EBERT, MH ;

CAINE, ED ;

REICHERT, CM ;

KOPIN, IJ .

PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254

[9] DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].

HEIKKILA, RE ;

HESS, A ;

DUVOISIN, RC .

SCIENCE, 1984, 224 (4656) :1451-1453

[10] DOPAMINERGIC TOXICITY OF ROTENONE AND THE 1-METHYL-4-PHENYLPYRIDINIUM ION AFTER THEIR STEREOTAXIC ADMINISTRATION TO RATS - IMPLICATION FOR THE MECHANISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY [J].

HEIKKILA, RE ;

NICKLAS, WJ ;

VYAS, I ;

DUVOISIN, RC .

NEUROSCIENCE LETTERS, 1985, 62 (03) :389-394

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