SELECTIVE REMOVAL OF FLUORENYLMETHOXYCARBONYL (FMOC) GROUPS UNDER MILD CONDITIONS

被引：12

作者：

JIANG, JJ ^{[1
]}

LI, WR ^{[1
]}

JOULLIE, MM ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 02期

关键词：

D O I：

10.1080/00397919408013818

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Fluorenylmethoxycarbonyl groups may be removed by potassium fluoride/18-crown-6 in the presence of methyl, ethyl, tert-butyl, benzyl, and p-methoxybenzyl esters.

引用

页码：187 / 195

页数：9

共 17 条

[11]

MIRANDA MTM, 1991, INT J PEPT PROT RES, V37, P128

[12] MEMBRANE-ASSISTED RECEPTOR SUBTYPE SELECTION - SYNTHESIS, MEMBRANE-STRUCTURE, AND OPIOID RECEPTOR AFFINITY OF [PHE8,12]DINORPHIN-(1-13)-TRIDECAPEPTIDE AND [PHE8,12,LYS10]DYNORPHIN-(1-13)-TRIDECAPEPTIDE [J].

NAKAJIMA, K ;

ERNE, D ;

BEAN, JW ;

SARGENT, DF ;

SCHWYZER, R ;

PATERSON, SJ ;

KOSTERLITZ, HW .

TETRAHEDRON, 1988, 44 (03) :721-732

[13] SYNTHESIS OF [2-SERINE, 8-VALINE] HUMAN CALCITONIN [J].

NOZAKI, S .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1978, 51 (10) :2995-3003

[14] 2-TRIMETHYLSILYLETHYL RESIDUE, A SELECTIVELY CLEAVABLE CARBOXYL PROTECTING GROUP [J].

SIEBER, P .

HELVETICA CHIMICA ACTA, 1977, 60 (08) :2711-2716

[15] FACILE REMOVAL OF A PEPTIDE-CHAIN FROM A SOLID-PHASE RESIN SUPPORT BY HYDROLYSIS USING TETRABUTYLAMMONIUM FLUORIDE TRIHYDRATE IN N,N-DIMETHYLFORMAMIDE [J].

UEKI, M ;

KAI, K ;

AMEMIYA, M ;

HORINO, H ;

OYAMADA, H .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (06) :414-415

[16] REMOVAL OF 9-FLUORENYLMETHYLOXYCARBONYL (FMOC) GROUP WITH TETRABUTYLAMMONIUM FLUORIDE [J].

UEKI, M ;

AMEMIYA, M .

TETRAHEDRON LETTERS, 1987, 28 (52) :6617-6620

[17]

UEKI M, 1987, 1987 PEPT CHEM P JAP, P223

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