SELECTIVE REMOVAL OF FLUORENYLMETHOXYCARBONYL (FMOC) GROUPS UNDER MILD CONDITIONS

被引：12

作者：

JIANG, JJ ^{[1
]}

LI, WR ^{[1
]}

JOULLIE, MM ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 02期

关键词：

D O I：

10.1080/00397919408013818

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Fluorenylmethoxycarbonyl groups may be removed by potassium fluoride/18-crown-6 in the presence of methyl, ethyl, tert-butyl, benzyl, and p-methoxybenzyl esters.

引用

页码：187 / 195

页数：9

共 17 条

[1] MILD PROCEDURE FOR SOLID-PHASE PEPTIDE-SYNTHESIS - USE OF "FLUORENYLMETHOXYCARBONYLAMINO-ACIDS [J].

ATHERTON, E ;

FOX, H ;

HARKISS, D ;

LOGAN, CJ ;

SHEPPARD, RC ;

WILLIAMS, BJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (13) :537-539

[2]

ATHERTON E, 1987, PEPTIDES ANAL SYNTHE, V9, P1

[3] A 3-DIMENSIONAL ORTHOGONAL PROTECTION SCHEME FOR SOLID-PHASE PEPTIDE-SYNTHESIS UNDER MILD CONDITIONS [J].

BARANY, G ;

ALBERICIO, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (17) :4936-4942

[4] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[5] 9-FLUORENYLMETHOXYCARBONYL FUNCTION, A NEW BASE-SENSITIVE AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (19) :5748-&

[6]

CARPINO LA, 1991, Patent No. 121

[7] COMPARATIVE-STUDY OF SELECTED COUPLING REAGENTS IN DIPEPTIDE SYNTHESIS [J].

DUDASH, J ;

JIANG, JJ ;

MAYER, SC ;

JOULLIE, MM .

SYNTHETIC COMMUNICATIONS, 1993, 23 (03) :349-356

[8]

IGARO K, 1981, B CHEM SOC JPN, V54, P3088

[9]

LI WR, 1993, TETRAHEDRON LETT, V34, P1413

[10]

LI WR, 1993, SYNLETT, P362

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