BINDING OF 1,2(N)-DIMETHYL-6,7-DIHYDROXY-ISOQUINOLINIUM ION TO MELANIN - EFFECTS OF FERROUS AND FERRIC ION ON THE BINDING

被引:29
作者
NAOI, M
MARUYAMA, W
DOSTERT, P
机构
[1] NAGOYA UNIV, SCH MED, DEPT NEUROL, NAGOYA 461, JAPAN
[2] FARM FARMITALIA CARLO ERBA, MILAN, ITALY
关键词
N-METHYLSALSOLINIUM ION; MELANIN; NEUROTOXIN; PARKINSONS DISEASE; ISOQUINOLINE; IRON;
D O I
10.1016/0304-3940(94)90591-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1,2(N)-Dimethyl-6,7-dihydroxy-isoquinoliniun (N-methylsalsolinium ion) was found to bind to melanin, while N-methyl(R)salsolinol and (R)salsolinol did not. Two components with different affinity to melanin were found; the dissociation constant and maximal binding capacity were obtained as 2.1 and 79.4 nM, and 103 and 1336 pmol/mg melanin, respectively. The binding was enhanced by ferrous ion markedly and inhibited by 1-methyl-4-phenylpyridinium ion and ferric ion. N-Methylsalsolinium ion may be accumulated in dopamine neurons as melanin conjugate, which is regulated by ferric and ferrous ions.
引用
收藏
页码:9 / 12
页数:4
相关论文
共 16 条
[1]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[2]   EVIDENCE FOR NEUROMELANIN INVOLVEMENT IN MPTP-INDUCED NEUROTOXICITY [J].
DAMATO, RJ ;
ALEXANDER, GM ;
SCHWARTZMAN, RJ ;
KITT, CA ;
PRICE, DL ;
SNYDER, SH .
NATURE, 1987, 327 (6120) :324-326
[3]   CHARACTERIZATION OF THE BINDING OF N-METHYL-4-PHENYLPYRIDINE, THE TOXIC METABOLITE OF THE PARKINSONIAN NEUROTOXIN N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE, TO NEUROMELANIN [J].
DAMATO, RJ ;
BENHAM, DF ;
SNYDER, SH .
JOURNAL OF NEUROCHEMISTRY, 1987, 48 (02) :653-658
[4]   BIOSYNTHESIS OF SALSOLINOL, A TETRAHYDROISOQUINOLINE ALKALOID, IN HEALTHY-SUBJECTS [J].
DOSTERT, P ;
BENEDETTI, MS ;
BELLOTTI, V ;
ALLIEVI, C ;
DORDAIN, G .
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1990, 81 (03) :215-223
[5]   MELANIZED DOPAMINERGIC-NEURONS ARE DIFFERENTIALLY SUSCEPTIBLE TO DEGENERATION IN PARKINSONS-DISEASE [J].
HIRSCH, E ;
GRAYBIEL, AM ;
AGID, YA .
NATURE, 1988, 334 (6180) :345-348
[6]   PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - UPTAKE OF THE METABOLITE N-METHYL-4-PHENYLPYRIDINE BY DOPAMINE NEURONS EXPLAINS SELECTIVE TOXICITY [J].
JAVITCH, JA ;
DAMATO, RJ ;
STRITTMATTER, SM ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2173-2177
[7]   CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].
LANGSTON, JW ;
BALLARD, P ;
TETRUD, JW ;
IRWIN, I .
SCIENCE, 1983, 219 (4587) :979-980
[8]   N-METHYLATION OF DOPAMINE-DERIVED 6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, (R)-SALSOLINOL, IN RAT BRAINS - INVIVO MICRODIALYSIS STUDY [J].
MARUYAMA, W ;
NAKAHARA, D ;
OTA, M ;
TAKAHASHI, T ;
TAKAHASHI, A ;
NAGATSU, T ;
NAOI, M .
JOURNAL OF NEUROCHEMISTRY, 1992, 59 (02) :395-400
[9]  
MARUYAMA W, 1993, ADV NEUROL, V60, P224
[10]   ACCUMULATION OF N-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) IN HUMAN-MELANOMA CELL-LINE, HMV-I AND HMV-II [J].
NAOI, M ;
TAKAHASHI, T ;
ITO, S ;
FUJITA, K ;
NAGATSU, T .
NEUROSCIENCE LETTERS, 1988, 87 (1-2) :57-62