BINDING OF 1,2(N)-DIMETHYL-6,7-DIHYDROXY-ISOQUINOLINIUM ION TO MELANIN - EFFECTS OF FERROUS AND FERRIC ION ON THE BINDING

被引：29

作者：

NAOI, M

MARUYAMA, W

DOSTERT, P

机构：

[1] NAGOYA UNIV, SCH MED, DEPT NEUROL, NAGOYA 461, JAPAN

[2] FARM FARMITALIA CARLO ERBA, MILAN, ITALY

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

N-METHYLSALSOLINIUM ION; MELANIN; NEUROTOXIN; PARKINSONS DISEASE; ISOQUINOLINE; IRON;

D O I：

10.1016/0304-3940(94)90591-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1,2(N)-Dimethyl-6,7-dihydroxy-isoquinoliniun (N-methylsalsolinium ion) was found to bind to melanin, while N-methyl(R)salsolinol and (R)salsolinol did not. Two components with different affinity to melanin were found; the dissociation constant and maximal binding capacity were obtained as 2.1 and 79.4 nM, and 103 and 1336 pmol/mg melanin, respectively. The binding was enhanced by ferrous ion markedly and inhibited by 1-methyl-4-phenylpyridinium ion and ferric ion. N-Methylsalsolinium ion may be accumulated in dopamine neurons as melanin conjugate, which is regulated by ferric and ferrous ions.

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页码：9 / 12

页数：4

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