IMPROVED METHOD FOR THE PREPARATION OF GUANIDINES

被引：250
作者：
KIM, KS
QIAN, LG
机构：
[1] The Bristol-Myeis Squibb Pharmaceutical Research Institute, NJ 08543-4000
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 48期
关键词：
D O I：
10.1016/S0040-4039(00)61537-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Use of N,N'-di-(tert-butoxycarbonyl)thiourea 1 in the presence of mercuric chloride provides a very efficient method for the bis-Boc protected guanidine formation of the amino compounds which are highly deactivated either sterically or electronically.
引用
收藏
页码：7677 / 7680
页数：4
相关论文
共 5 条
[1]   1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE - AN ATTRACTIVE REAGENT FOR GUANYLATION OF AMINES AND ITS APPLICATION TO PEPTIDE-SYNTHESIS [J].
BERNATOWICZ, MS ;
WU, YL ;
MATSUEDA, GR .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (08) :2497-2502
[2]   PREPARATION OF N,N'-BIS-TERT-BUTOXYCARBONYLTHIOUREA [J].
IWANOWICZ, EJ ;
POSS, MA ;
LIN, J .
SYNTHETIC COMMUNICATIONS, 1993, 23 (10) :1443-1445
[3]  
MILLER AE, 1986, SYNTHESIS-STUTTGART, P777
[4]   A MILD AND EFFICIENT METHOD FOR THE PREPARATION OF GUANIDINES [J].
POSS, MA ;
IWANOWICZ, E ;
REID, JA ;
LIN, J ;
GU, ZX .
TETRAHEDRON LETTERS, 1992, 33 (40) :5933-5936
[5]  
YAMAMOTO Y, 1991, CHEM AMIDINES IMIDAT, V2, pCH10
1