CORRELATION BETWEEN CEREBROSPINAL-FLUID PHENYLALANINE AND BETA-ENDORPHIN IN PATIENTS WITH PHENYLKETONURIA

被引：1
作者：
BACH, FW
NIELSEN, JB
BUCHHOLT, J
LOU, H
GUTTLER, F
机构：
[1] GENTOFTE HOSP,DEPT CLIN CHEM,DK-2900 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,RIGSHOSP,DEPT NEUROL,DK-2100 COPENHAGEN,DENMARK
[3] UNIV COPENHAGEN,RIGSHOSP,DEPT PAEDIAT,DK-2100 COPENHAGEN,DENMARK
[4] JOHN F KENNEDY INST,GLOSTRUP,DENMARK
来源：
NEUROSCIENCE LETTERS | 1991年 / 129卷 / 01期
关键词：
ENDORPHIN; ANALGESIA; CEREBROSPINAL FLUID; PHENYLALANINE; BETA-ENDORPHIN; PHENYLKETONURIA;
D O I：
10.1016/0304-3940(91)90737-E
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous animal and human studies have suggested an analgesic effect of phenylalanine involving endogenous opioid peptides. Phenylalanine was measured by a HPLC method with electrochemical detection and beta-endorphin by a specific radioimmunoassay in 14 lumbar cerebrospinal fluid samples from 13 patients with phenylketonuria. Cerebrospinal fluid beta-endorphin was also determined in 6 age-matched control subjects. We found a trend towards a higher beta-endorphin level in phenylketonuria (median 26.0 pM, range 13.0-37.8) than in the control subjects (20.6 pM, 12.7-28.0), P = 0.13. Cerebrospinal fluid concentrations of phenylalanine and beta-endorphin were significantly correlated (r = 0.68, P = 0.008). The results support the hypothesis that phenylalanine modifies the central endogenous opioid system.
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收藏
页码：131 / 133
页数：3
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