PYRUVATE-DEHYDROGENASE ACTIVATION IN ADIPOCYTE MITOCHONDRIA BY AN INSULIN-GENERATED MEDIATOR FROM MUSCLE

被引：191
作者：
JARETT, L
SEALS, JR
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63130
[2] BARNES HOSP,ST LOUIS,MO 63110
来源：
SCIENCE | 1979年 / 206卷 / 4425期
关键词：
D O I：
10.1126/science.505013
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Material in a Chromatographic fraction from an extract of insulintreated muscle stimulated pyruvate dehydrogenase activity in adipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the Chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.
引用
收藏
页码：1407 / 1408
页数：2
相关论文
共 11 条
[1]   PYRUVATE-DEHYDROGENASE AND HORMONAL-REGULATION OF FAT SYNTHESIS IN MAMMALIAN-TISSUES [J].
DENTON, RM ;
HUGHES, WA .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1978, 9 (08) :545-552
[2]   GENERATION BY INSULIN OF A CHEMICAL MEDIATOR THAT CONTROLS PROTEIN-PHOSPHORYLATION AND DEPHOSPHORYLATION [J].
LARNER, J ;
GALASKO, G ;
CHENG, K ;
DEPAOLIROACH, AA ;
HUANG, L ;
DAGGY, P ;
KELLOGG, J .
SCIENCE, 1979, 206 (4425) :1408-1410
[3]  
MAY JM, 1979, J BIOL CHEM, V254, P2214
[4]   ABILITY OF INSULIN TO ALTER STABLE CALCIUM POOLS OF ISOLATED ADIPOCYTE SUBCELLULAR-FRACTIONS [J].
MCDONALD, JM ;
BRUNS, DE ;
JARETT, L .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 71 (01) :114-121
[5]  
SEALS JR, 1979, J BIOL CHEM, V254, P6991
[6]   DIRECT EFFECT OF INSULIN ON LABELING OF ISOLATED PLASMA-MEMBRANES BY [GAMMA-P-32] ATP [J].
SEALS, JR ;
MCDONALD, JM ;
JARETT, L .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (04) :1365-1372
[7]  
SEALS JR, 1979, J BIOL CHEM, V254, P6997
[8]  
SEALS JR, P NATL ACAD SCI US
[9]   EXCHANGEABLE AND TOTAL CALCIUM POOLS IN MITOCHONDRIA OF RAT EPIDIDYMAL FAT-PADS AND ISOLATED FAT-CELLS - ROLE IN REGULATION OF PYRUVATE-DEHYDROGENASE ACTIVITY [J].
SEVERSON, DL ;
DENTON, RM ;
BRIDGES, BJ ;
RANDLE, PJ .
BIOCHEMICAL JOURNAL, 1976, 154 (01) :209-223
[10]   CALCIUM AND MAGNESIUM-IONS AS EFFECTORS OF ADIPOSE-TISSUE PYRUVATE-DEHYDROGENASE PHOSPHATE PHOSPHATASE [J].
SEVERSON, DL ;
DENTON, RM ;
PASK, HT ;
RANDLE, PJ .
BIOCHEMICAL JOURNAL, 1974, 140 (02) :225-237
12