THE PHARMACOLOGY OF METHOTREXATE

被引：126
作者：
OLSEN, EA
机构：
[1] Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 25卷 / 02期
关键词：
D O I：
10.1016/0190-9622(91)70199-C
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.
引用
收藏
页码：306 / 318
页数：13
相关论文
共 102 条
[1]   METHOTREXATE-INDUCED RENAL IMPAIRMENT - CLINICAL-STUDIES AND RESCUE FROM SYSTEMIC TOXICITY WITH HIGH-DOSE LEUCOVORIN AND THYMIDINE [J].
ABELSON, HT ;
FOSBURG, MT ;
BEARDSLEY, P ;
GOORIN, AM ;
GORKA, C ;
LINK, M ;
LINK, D .
JOURNAL OF CLINICAL ONCOLOGY, 1983, 1 (03) :208-216
[2]   WEEKLY PULSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - CLINICAL AND IMMUNOLOGICAL EFFECTS IN A RANDOMIZED, DOUBLE-BLIND-STUDY [J].
ANDERSEN, PA ;
WEST, SG ;
ODELL, JR ;
VIA, CS ;
CLAYPOOL, RG ;
KOTZIN, BL .
ANNALS OF INTERNAL MEDICINE, 1985, 103 (04) :489-496
[3]   IS METHOTREXATE THERAPY FOR PSORIASIS CARCINOGENIC - MODIFIED RETROSPECTIVE PROSPECTIVE ANALYSIS [J].
BAILIN, PL ;
TINDALL, JP ;
ROENIGK, HH ;
HOGAN, MD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 232 (04) :359-362
[4]   INTERMITTENT HIGH DOSE ORAL METHOTREXATE THERAPY IN PSORIASIS [J].
BAKER, H .
BRITISH JOURNAL OF DERMATOLOGY, 1970, 82 (01) :65-&
[5]  
BALIS FM, 1983, CANCER RES, V43, P2342
[6]  
BENDER RA, 1975, CANCER CHEMOTH REP 3, V6, P73
[7]   CLINICAL-PHARMACOLOGY OF METHOTREXATE [J].
BERTINO, JR .
MEDICAL AND PEDIATRIC ONCOLOGY, 1982, 10 (04) :401-411
[8]  
BLASBERG RG, 1975, J PHARMACOL EXP THER, V195, P73
[9]  
Bleyer W A, 1977, Natl Cancer Inst Monogr, V46, P171
[10]  
BLEYER WA, 1978, CANCER-AM CANCER SOC, V41, P36, DOI 10.1002/1097-0142(197801)41:1<36::AID-CNCR2820410108>3.0.CO
12345678910