Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform

被引:54
|
作者
Angsantikul, Pavimol
Thamphiwatana, Soracha
Gao, Weiwei
Zhang, Liangfang [1 ]
机构
[1] Univ Calif San Diego, Dept NanoEngn, San Diego, CA 92093 USA
来源
VACCINES | 2015年 / 3卷 / 04期
关键词
nanomedicine; nanovaccine; biomimetic nanoparticle; membrane coating; infectious disease;
D O I
10.3390/vaccines3040814
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.
引用
收藏
页码:814 / 828
页数:15
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