EFFECTS OF METHYLENEDIOXYMETHAMPHETAMINE ON THE RELEASE OF MONOAMINES FROM RAT-BRAIN SLICES

被引：59
作者：
FITZGERALD, JL
REID, JJ
机构：
[1] Department of Pharmacology, University of Melbourne, Melbourne
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 02期
关键词：
5-HT; (5-hydroxytryptamine; serotonin); Brain slices (rat; superfused); Dopamine; MDMA (3,4-methylenedioxymethamphetamine); Monoamine release; Noradrenaline;
D O I：
10.1016/0014-2999(90)94150-V
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 μM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 μM) were blocked by the neuronal uptake inhibitors, cocaine (10 μM), fluoxetine (1 μM) and desmethylhnipramine (1 μM), respectively. MDMA (10 μM) enhanced the stimulation-induced efflux of radioactivity from slices incubated in [3H]noradrenaline but not from slices incubated in [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first time a direct noradrenaline-releasing action of MDMA and differential effects of MDMA on the stimulation-induced release of noradrenaline, dopamine and 5-hydroxytryptamine from rat superfused brain slices. © 1990.
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页码：217 / 220
页数：4
相关论文
共 9 条
[1]   METHYSERGIDE POTENTIATES THE HYPERACTIVITY PRODUCED BY MDMA IN RATS [J].
GOLD, LH ;
KOOB, GF .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (03) :645-648
[2]   5-HYDROXYTRYPTAMINE UPTAKE BLOCKERS ATTENUATE THE 5-HYDROXYTRYPTAMINE-RELEASING EFFECT OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND RELATED AGENTS [J].
HEKMATPANAH, CR ;
PEROUTKA, SJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 177 (1-2) :95-98
[3]   DIFFERENCES BETWEEN THE RELEASE OF RADIOLABELED AND ENDOGENOUS DOPAMINE FROM SUPERFUSED RAT-BRAIN SLICES - EFFECTS OF DEPOLARIZING STIMULI, AMPHETAMINE AND SYNTHESIS INHIBITION [J].
HERDON, H ;
STRUPISH, J ;
NAHORSKI, SR .
BRAIN RESEARCH, 1985, 348 (02) :309-320
[4]   BRAIN CATECHOLAMINES IN SCHIZOPHRENIA - A GOOD CASE FOR NORADRENALINE [J].
HORNYKIEWICZ, O .
NATURE, 1982, 299 (5883) :484-486
[5]  
HUBNER CB, 1988, PSYCHOPHARMACOLOGY, V95, P49
[6]   EFFECTS OF THE ENANTIOMERS OF MDA, MDMA AND RELATED ANALOGS ON [H-3] SEROTONIN AND [H-3] DOPAMINE RELEASE FROM SUPERFUSED RAT-BRAIN SLICES [J].
JOHNSON, MP ;
HOFFMAN, AJ ;
NICHOLS, DE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 132 (2-3) :269-276
[7]   EFFECTS OF CERTAIN HALLUCINOGENIC AMPHETAMINE ANALOGS ON THE RELEASE OF [H-3]-LABELED SEROTONIN FROM RAT-BRAIN SYNAPTOSOMES [J].
NICHOLS, DE ;
LLOYD, DH ;
HOFFMAN, AJ ;
NICHOLS, MB ;
YIM, GKW .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (05) :530-535
[8]   INVITRO AND INVIVO NEUROCHEMICAL EFFECTS OF METHYLENEDIOXYMETHAMPHETAMINE ON STRIATAL MONOAMINERGIC SYSTEMS IN THE RAT-BRAIN [J].
SCHMIDT, CJ ;
LEVIN, JA ;
LOVENBERG, W .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (05) :747-755
[9]   STEREOCHEMICAL EFFECTS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) AND RELATED AMPHETAMINE DERIVATIVES ON INHIBITION OF UPTAKE OF [H-3] MONOAMINES INTO SYNAPTOSOMES FROM DIFFERENT REGIONS OF RAT-BRAIN [J].
STEELE, TD ;
NICHOLS, DE ;
YIM, GKW .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (14) :2297-2303
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