HOPE FOR SUCCESSFUL XENOGRAFTING BY IMMUNOSUPPRESSION WITH MONOCLONAL-ANTIBODY AGAINST CD4, TOTAL LYMPHOID IRRADIATION AND CYCLOSPORINE - 6 MONTHS SURVIVAL OF HAMSTER HEART TRANSPLANTED INTO RAT

被引：5

作者：

KEMP, E

DIEPERINK, H

JENSENIUS, JC

KOCH, C

LARSEN, S

MADSEN, HHT

NIELSEN, B

STARKLINT, H

STEINBRUCHEL, DA

机构：

[1] NATL SERUM INST,COPENHAGEN,DENMARK

[2] ODENSE UNIV HOSP,INST PHYS & ASTROPHYS,DK-5000 ODENSE,DENMARK

[3] HERLEV HOSP,DEPT PATHOL,DK-2730 HERLEV,DENMARK

来源：

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 1990年 / 24卷 / 01期

关键词：

Anti-CD4; Cyclosporine; Monoclonal antibodies; Tolerance; Total lymphoid irradiation; Xenotransplantation;

D O I：

10.3109/00365599009180365

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hamster hearts were transplanted to rats, and the effects of combinations of total lymphoid irradiation (TLI), cyclophosphamide, cyclosporine A (CyA) and monoclonal antibodies (MAB) were investigated, Controls not immunosuppressed rejected their xenograft in 3 to 5 days, while combination immunosuppression including MABs against CD4 or IL-2-receptors extended graft survival significantly, In one case, the graft was still functioning 180 days after transplantation, which is the longest survival seen in this model. The use of specific MABs may open a new era for both xeno- and allo-transplantation. © 1990 Informa UK Ltd.

引用

页码：79 / 80

页数：2