EFFECT OF KETANSERIN, A NEW BLOCKING-AGENT OF THE 5-HT2-RECEPTOR, ON AIRWAY RESPONSIVENESS IN ASTHMA

被引：16

作者：

CAZZOLA, M

ASSOGNA, G

LUCCHETTI, G

CICCHITTO, G

DAMATO, G

机构：

[1] Occupational Pulmonary Disease Service, Department of Pulmonary Medicine, A. Cardarelli Hospital, Naples

来源：

ALLERGY | 1990年 / 45卷 / 02期

关键词：

5HT[!sub]2[!/sub] receptors; bronchial asthma; ketanserin; methacholine induced broncho‐constriction;

D O I：

10.1111/j.1398-9995.1990.tb00473.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Most of the antihypertensive drugs have a liability for adverse effects in asthma. Since there are few available data on the effect of ketanserin, a new antihypertensive drug which is a type‐2 serotonin receptor antagonist, on human respiratory function, we have tested whether this drug can modify bronchial hyperresponsiveness to methacholine in asthmatic patients. The protective effect of intravenous ketanserin (0.14 mg/kg) was small, but significant. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：151 / 153

页数：3

共 11 条

[1] KETANSERIN, A NEW BLOCKING-AGENT OF SEROTONIN S-2-RECEPTORS - RESPIRATORY FUNCTIONAL-EFFECTS IN CHRONIC OBSTRUCTION OF THE AIRWAYS [J].