TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-DEOXYTAXOL

被引：61

作者：

CHEN, SH

WEI, JM

FARINA, V

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492-7660

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)73661-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Deoxy taxol 2 was prepared in nine steps from baccatin III; the key step of the synthesis is a Barton-type deoxygenation at C-2. The compound was found to possess much reduced antitumor activity with respect to taxol.

引用

页码：3205 / 3206

页数：2

共 7 条

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