ON THE RAT MODEL OF HUMAN OSTEOPENIAS AND OSTEOPOROSIS

被引：373
作者：
FROST, HM
JEE, WSS
机构：
[1] UNIV UTAH, SCH MED, DIV RADIOBIOL, BLDG 586, SALT LAKE CITY, UT 84112 USA
[2] SO COLORADO CLIN, DEPT ORTHOPAED SURG, PUEBLO, CO USA
来源：
BONE AND MINERAL | 1992年 / 18卷 / 03期
关键词：
RAT; OSTEOPOROSIS; OSTEOPENIA; BONE MODELING; BONE REMODELING; MECHANICAL AND NONMECHANICAL AGENTS;
D O I：
10.1016/0169-6009(92)90809-R
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.
引用
收藏
页码：227 / 236
页数：10
相关论文
共 98 条
[81]  
Thomsen K, 1986, J Bone Miner Res, V1, P503
[82]  
TIDA K, 1990, BONE MORPHOMETRY, P448
[83]  
TURNER RT, 1987, J BONE MINER RES, V2, P115
[84]   CELLULAR KINETICS OF THE BONE REMODELING SEQUENCE IN THE RAT [J].
VAN, PT ;
VIGNERY, A ;
BARON, R .
ANATOMICAL RECORD, 1982, 202 (04) :445-451
[85]  
VICO L, 1991, CELLS MAT S, V1, P143
[86]   DYNAMIC HISTOMORPHOMETRY OF ALVEOLAR BONE REMODELING IN THE ADULT-RAT [J].
VIGNERY, A ;
BARON, R .
ANATOMICAL RECORD, 1980, 196 (02) :191-200
[87]  
WAKLEY GK, 1991, CELL MATER, P85
[88]   INTERMITTENT CYCLICAL ETIDRONATE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS [J].
WATTS, NB ;
HARRIS, ST ;
GENANT, HK ;
WASNICH, RD ;
MILLER, PD ;
JACKSON, RD ;
LICATA, AA ;
ROSS, P ;
WOODSON, GC ;
YANOVER, MJ ;
MYSIW, WJ ;
KOHSE, L ;
RAO, MB ;
STEIGER, P ;
RICHMOND, B ;
CHESNUT, CH .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (02) :73-79
[89]   EFFECTS OF CASTRATION ON THE BONE-STRUCTURE OF MALE-RATS - A MODEL OF OSTEOPOROSIS [J].
WINK, CS ;
FELTS, WJL .
CALCIFIED TISSUE INTERNATIONAL, 1980, 32 (01) :77-82
[90]  
WOODARD JC, 1991, VET CLIN N AM-SMALL, V21, P813, DOI 10.1016/S0195-5616(91)50085-1
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