DIRECTED RESOLUTIONS OF ENANTIOMERS VIA LIQUID-CHROMATOGRAPHY OF DIASTEREOMERIC DERIVATIVES .6. PREPARATIVE SCALE DIRECTED RESOLUTION OF ENANTIOMERIC AMINES VIA LIQUID-CHROMATOGRAPHY OF DIASTEREOMERIC 4-HYDROXYBUTYRAMIDES

被引：53

作者：

HELMCHEN, G

NILL, G

机构：

[1] Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität, Stuttgart, D-7000

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1979年 / 18卷 / 01期

关键词：

D O I：

10.1002/anie.197900651

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The separation of enantiomeric amines 1 on a preparative scale can be carried out by the same principles as used in the separation of enantiomeric carboxylic acids. However, there is no simple access to amides bearing α‐substituents in the acidic moiety; the corresponding 2‐alkylbutyrolactones racemize. 3‐Substituted butyrolactones such as 2 proved to be suitable reagents. (Figure Presented.) Copyright © 1979 by Verlag Chemie, GmbH, Germany

引用

页码：65 / 66

页数：2

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[1] DIRECTED RESOLUTION OF ENANTIOMERS VIA LIQUID CHROMATOGRAPHY OF DIASTEREOMERIC DERIVATIVES .5. PREPARATIVE SCALE DIRECTED RESOLUTION OF ENANTIOMERIC CARBOXYLIC-ACIDS AND LACTONES VIA LIQUID-CHROMATOGRAPHY AND NEIGHBORING-GROUP ASSISTED HYDROLYSIS OF DIASTEREOMERIC AMIDES [J].