REACTION OF IRON BLEOMYCIN WITH THIOLS AND OXYGEN

被引：41

作者：

ANTHOLINE, WE ^{[1
]}

PETERING, DH ^{[1
]}

机构：

[1] UNIV WISCONSIN, DEPT CHEM, MOLEC BIOMED RES LAB, MILWAUKEE, WI 53201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91636-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron(III)bleomycin undergoes a redox reaction with thiols. Evidence from epr and UV-visible absorbance spectra indicate that the metal complex forms an intermediate with sulfhydryl groups presumably by adding a sixth ligand. In the presence of oxygen iron bleomycin cycles between its two oxidation states to catalyze the generation of oxygen free radicals using thiols as a source of electrons. © 1979.

引用

页码：384 / 389

页数：6

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