EFFECT OF 5,10-METHYLENETETRAHYDROFOLATE ON DISSOCIATION OF 5-FLUORO-2'-DEOXYURIDYLATE FROM THYMIDYLATE SYNTHETASE - EVIDENCE FOR AN ORDERED MECHANISM

被引：185
作者：
DANENBERG, PV [1 ]
DANENBERG, KD [1 ]
机构：
[1] UNIV SO CALIF,LOS ANGELES CTY COMPREHENS CANC CTR,SCH MED,LOS ANGELES,CA 90031
来源：
BIOCHEMISTRY | 1978年 / 17卷 / 19期
关键词：
D O I：
10.1021/bi00612a022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：4018 / 4024
页数：7
相关论文
共 36 条
[1]   SEPARATION, IDENTIFICATION, AND STOICHIOMETRY OF TERNARY COMPLEXES OF THYMIDYLATE SYNTHETASE [J].
AULL, JL ;
LYON, JA ;
DUNLAP, RB .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 165 (02) :805-808
[2]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[3]  
BLAKLEY RL, 1963, J BIOL CHEM, V238, P2113
[4]  
CLELAND WW, 1967, ADV ENZYMOL RAMB, V29, P1
[5]   KINETICS OF ENZYME-CATALYZED REACTIONS WITH 2 OR MORE SUBSTRATES OR PRODUCTS .1. NOMENCLATURE AND RATE EQUATIONS [J].
CLELAND, WW .
BIOCHIMICA ET BIOPHYSICA ACTA, 1963, 67 (01) :104-&
[6]   PARTITION ANALYSIS AND CONCEPT OF NET RATE CONSTANTS AS TOOLS IN ENZYME-KINETICS [J].
CLELAND, WW .
BIOCHEMISTRY, 1975, 14 (14) :3220-3224
[7]  
CLELAND WW, 1963, BIOCH BIOPHYS ACTA, V67, P138
[8]   THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES [J].
COHEN, SS ;
FLAKS, JG ;
BARNER, HD ;
LOEB, MR ;
LICHTENSTEIN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1958, 44 (10) :1004-1012
[9]   STRUCTURES OF REVERSIBLE AND IRREVERSIBLE COMPLEXES OF THYMIDYLATE SYNTHETASE AND FLUORINATED PYRIMIDINE NUCLEOTIDES [J].
DANENBER.PV ;
LANGENBA.RJ ;
HEIDELBE.C .
BIOCHEMISTRY, 1974, 13 (05) :926-933
[10]   USE OF CHROMIUM-ADENOSINE TRIPHOSPHATE AND LYXOSE TO ELUCIDATE KINETIC MECHANISM AND COORDINATION STATE OF NUCLEOTIDE SUBSTRATE FOR YEAST HEXOKINASE [J].
DANENBERG, KD ;
CLELAND, WW .
BIOCHEMISTRY, 1975, 14 (01) :28-39
1234