THE ACTION OF SYNTHETIC CANNABINOIDS ON THE INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

被引：57

作者：

COLLINS, DR ^{[1
]}

PERTWEE, RG ^{[1
]}

DAVIES, SN ^{[1
]}

机构：

[1] UNIV ABERDEEN, MARISCHAL COLL, DEPT BIOMED SCI, ABERDEEN AB9 1AS, SCOTLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期

关键词：

CANNABINOID; LONG-TERM POTENTIATION; HIPPOCAMPUS;

D O I：

10.1016/0014-2999(94)90666-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.

引用

页码：R7 / R8

页数：2

共 8 条

[1] NONPSYCHOTROPIC CANNABINOID ACTS AS A FUNCTIONAL N-METHYL-D-ASPARTATE RECEPTOR BLOCKER [J].

FEIGENBAUM, JJ ;

BERGMANN, F ;

RICHMOND, SA ;

MECHOULAM, R ;

NADLER, V ;

KLOOG, Y ;

SOKOLOVSKY, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9584-9587

[2] CHARACTERIZATION AND LOCALIZATION OF CANNABINOID RECEPTORS IN RAT-BRAIN - A QUANTITATIVE INVITRO AUTORADIOGRAPHIC STUDY [J].

HERKENHAM, M ;

LYNN, AB ;

JOHNSON, MR ;

MELVIN, LS ;

DECOSTA, BR ;

RICE, KC .

JOURNAL OF NEUROSCIENCE, 1991, 11 (02) :563-583

[3]

Mechoulam R., 1992, MARIJUANA CANNABINOI, P1

[4] CANNABIS - EFFECTS ON MEMORY AND THE CHOLINERGIC LIMBIC SYSTEM [J].

MILLER, LL ;

BRANCONNIER, RJ .

PSYCHOLOGICAL BULLETIN, 1983, 93 (03) :441-456

[5] BLOCKADE OF CA-45(2+) INFLUX THROUGH THE N-METHYL-D-ASPARTATE RECEPTOR-ION CHANNEL BY THE NON-PSYCHOACTIVE CANNABINOID HU-211 [J].

NADLER, V ;

MECHOULAM, R ;

SOKOLOVSKY, M .

BRAIN RESEARCH, 1993, 622 (1-2) :79-85

[6] THE MODULATION OF LONG-TERM POTENTIATION BY DELTA-9-TETRAHYDROCANNABINOL IN THE RAT HIPPOCAMPUS, INVITRO [J].

NOWICKY, AV ;

TEYLER, TJ ;

VARDARIS, RM .

BRAIN RESEARCH BULLETIN, 1987, 19 (06) :663-672

[7] INHIBITORY EFFECTS OF CERTAIN ENANTIOMERIC CANNABINOIDS IN THE MOUSE VAS-DEFERENS AND THE MYENTERIC PLEXUS PREPARATION OF GUINEA-PIG SMALL-INTESTINE [J].

PERTWEE, RG ;

STEVENSON, LA ;

ELRICK, DB ;

MECHOULAM, R ;

CORBETT, AD .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (04) :980-984

[8]

PERTWEE RG, 1992, MARIJUANA CANNABINOI, P165

← 1 →