MONOCLONAL ANTI-BIOTIN ANTIBODIES SIMULATE AVIDIN IN THE RECOGNITION OF BIOTIN

被引：40
作者：
BAGCI, H
KOHEN, F
KUSCUOGLU, U
BAYER, EA
WILCHEK, M
机构：
[1] WEIZMANN INST SCI,DEPT BIOPHYS,IL-76100 REHOVOT,ISRAEL
[2] WEIZMANN INST SCI,DEPT HORMONE RES,IL-76100 REHOVOT,ISRAEL
来源：
FEBS LETTERS | 1993年 / 322卷 / 01期
关键词：
ANTI-BIOTIN ANTIBODY; ANTIBODY GENE; BIOTIN BINDING SITE; ANTIBODY COMBINING SITE; BINDING MOTIF;
D O I：
10.1016/0014-5793(93)81108-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sequence of the V(H) gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementarity determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.
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页码：47 / 50
页数：4
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