CHARACTERIZATION OF FUROSEMIDE-INDUCED ACTIVATION OF THE RENAL PROSTAGLANDIN SYSTEM

被引：86

作者：

CIABATTONI, G ^{[1
]}

PUGLIESE, F ^{[1
]}

CINOTTI, GA ^{[1
]}

STIRATI, G ^{[1
]}

RONCI, R ^{[1
]}

CASTRUCCI, G ^{[1
]}

PIERUCCI, A ^{[1
]}

PATRONO, C ^{[1
]}

机构：

[1] UNIV ROME, DEPT MED 2, I-00100 ROME, ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 2-3期

关键词：

Furosemide; Renal prostaglandins; Renin radioimmunoassay; Thromboxane B[!sub]2[!/sub;

D O I：

10.1016/0014-2999(79)90217-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A detailed time course of changes in plasma renin activity (PRA), urinary prostaglandin (PG) E2, PGF2.alpha., thromboxane (TX) B2 and Na excretion rates after furosemide was obtained in 7 women. PRA increased within the first 15 min and remained elevated all through the experiment. PGE2, PGF2.alpha., TXB2 and Na increased simultaneously, reached a peak 15-45 min after furosemide and declined thereafter. Apparently, furosemide induces a generalized activation of the renal PG system temporally related to the increase in renin release and natriuresis.

引用

页码：181 / 187

页数：7

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