Comparison of IGF-1, IGFBP-3, and Estradiol Levels in Cyst Fluid and Serums of Postmenopausal Women with Benign and Malignant Tumor

Purpose: Ovarian cancer is the most significant cause of morbidity arid mortality among gynecologic cancers. Recently, effects of sex steroids and IGF/IGFUP system, which are the most important risk factors of ovarian cancer, has been investigated. In the present study, vie compared the IGF-1, IGFBP-3, arid estradiol levels in cyst fluid and serums of postmenopausal women with benign and malignant ovarian tumor. Materials and Methods: In total, 28 patients,12 patients with malignant ovarian tumor and 16 patients with benign ovarian tumor, were included in the study. In order to minimize the hormonal changes taking place Curing menstrual cycle, only postmenopausal patients were included in the present study. IGF-1, IGFBP-3, and estradiol levels were measured in cyst fluid and serums. Results: Estradiol level in cyst fluid of patients with malignant ovarian tumor, was significantly high. IGF-1 and IGFBP-3 levels measured in cyst fluid and serums, did not show a significant difference between patients with benign arid malignant ovarian tumors. Conclusion: The present study supported the hypothesis proposing an association between estradiol and ovarian carcinogenesis. Further studies are required to understand the importance of microenvironment during tumor growth.