Severe Direct Hyperbilirubinemia as a Consequence of Right Heart Failure in Congenital Heart Disease

被引：4

作者：

Philip, Joseph ^{[1
]}

Samraj, Ravi S. ^{[2
]}

Lopez-Colon, Dalia ^{[1
]}

Gonzalez-Peralta, Regino ^{[3
]}

Chandran, Arun ^{[1
]}

Bleiwies, Mark S. ^{[1
]}

机构：

[1] Univ Florida, Dept Pediat, Shands Childrens Hosp, Congenital Heart Ctr, Gainesville, FL USA

[2] Univ Florida, Dept Pediat, Shands Childrens Hosp, Div Crit Care, Gainesville, FL USA

[3] Univ Florida, Shands Childrens Hosp, Div Pediat Gastroenterol, Gainesville, FL USA

来源：

WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY | 2018年 / 9卷 / 04期

关键词：

heart failure; hyperbilirubinemia; tricuspid regurgitation; congenital heart surgery; CHD;

D O I：

10.1177/2150135116640786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult literature documents increased cholestasis in right heart failure yet is poorly documented in the pediatric population. We describe three infants with congenital heart disease who developed significantly elevated direct bilirubin levels of 43, 23, and 12 mg/dL, respectively, in the absence of hepatic dysfunction. The common hemodynamic pathophysiology in these infants is right heart dysfunction with moderate to severe tricuspid regurgitation in the setting of low perfusion state. Right heart dysfunction in infants can result in severe conjugated bilirubin, likely as a consequence of venous congestion and can be used as an indirect marker of right heart dynamics

引用

页码：470 / 474

页数：5

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